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ins receptor antagonist s961  (MedChemExpress)


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    MedChemExpress ins receptor antagonist s961
    Anti-inflammatory protein components in hucMSC-EXOs. ( A-F ) qPCR was performed to compare the effects of heat-inactivated hucMSC-EXOs and untreated hucMSC-EXOs on the expression levels of inflammatory cytokines in macrophages. ( G ) Topological analysis of hucMSC-EXOs proteins (top 200 by IBAQ value) via the STRING database, identifying the top 40 hub proteins ranked by interaction degree. Their degrees of interaction are visualized as a concentric circle plot. ( H-K ) ELISA was used to detect the <t>INS</t> ( H-I ) content and SOD1 ( J-K ) content of the hucMSCs culture supernatant and hucMSC-EXOs. (L‒O) qPCR analysis the effects of EXO alone, EXO combined with <t>S961,</t> and EXO combined with ATN-224 on the expression of inflammatory factors in macrophages. ( P ) WB experiment analysis the influence of EXO alone, EXO combined with S961, and EXO combined with ATN-224 treatment on PI3K/AKT and P65 phosphorylation in macrophages. * P < 0.05; ** P < 0.01 ; *** P < 0.001
    Ins Receptor Antagonist S961, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ins receptor antagonist s961/product/MedChemExpress
    Average 93 stars, based on 8 article reviews
    ins receptor antagonist s961 - by Bioz Stars, 2026-02
    93/100 stars

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    1) Product Images from "hucMSC-derived exosomes targeting macrophage polarization attenuate systemic inflammation in T1DM via INS/SOD1 delivery"

    Article Title: hucMSC-derived exosomes targeting macrophage polarization attenuate systemic inflammation in T1DM via INS/SOD1 delivery

    Journal: Stem Cell Research & Therapy

    doi: 10.1186/s13287-025-04521-0

    Anti-inflammatory protein components in hucMSC-EXOs. ( A-F ) qPCR was performed to compare the effects of heat-inactivated hucMSC-EXOs and untreated hucMSC-EXOs on the expression levels of inflammatory cytokines in macrophages. ( G ) Topological analysis of hucMSC-EXOs proteins (top 200 by IBAQ value) via the STRING database, identifying the top 40 hub proteins ranked by interaction degree. Their degrees of interaction are visualized as a concentric circle plot. ( H-K ) ELISA was used to detect the INS ( H-I ) content and SOD1 ( J-K ) content of the hucMSCs culture supernatant and hucMSC-EXOs. (L‒O) qPCR analysis the effects of EXO alone, EXO combined with S961, and EXO combined with ATN-224 on the expression of inflammatory factors in macrophages. ( P ) WB experiment analysis the influence of EXO alone, EXO combined with S961, and EXO combined with ATN-224 treatment on PI3K/AKT and P65 phosphorylation in macrophages. * P < 0.05; ** P < 0.01 ; *** P < 0.001
    Figure Legend Snippet: Anti-inflammatory protein components in hucMSC-EXOs. ( A-F ) qPCR was performed to compare the effects of heat-inactivated hucMSC-EXOs and untreated hucMSC-EXOs on the expression levels of inflammatory cytokines in macrophages. ( G ) Topological analysis of hucMSC-EXOs proteins (top 200 by IBAQ value) via the STRING database, identifying the top 40 hub proteins ranked by interaction degree. Their degrees of interaction are visualized as a concentric circle plot. ( H-K ) ELISA was used to detect the INS ( H-I ) content and SOD1 ( J-K ) content of the hucMSCs culture supernatant and hucMSC-EXOs. (L‒O) qPCR analysis the effects of EXO alone, EXO combined with S961, and EXO combined with ATN-224 on the expression of inflammatory factors in macrophages. ( P ) WB experiment analysis the influence of EXO alone, EXO combined with S961, and EXO combined with ATN-224 treatment on PI3K/AKT and P65 phosphorylation in macrophages. * P < 0.05; ** P < 0.01 ; *** P < 0.001

    Techniques Used: Expressing, Enzyme-linked Immunosorbent Assay, Phospho-proteomics

    S961 and ATN-224 partially reversed the therapeutic effect of hucMSC-EXOs on T1DM mice. ( A ) Schematic diagram shows the treatment plan for T1DM mice with S961, ATN-224 and hucMSC-EXOs. ( B ) Images of T1DM, EXO, EXO + S961, EXO + ATN-224 mice. ( C-F ) Physiological and metabolic indices, including food intake ( C ), water intake ( D ), body weight ( E ), and blood glucose levels ( F ), of the mice in the four groups. ( n = 6). ( G-H ) Glucose metabolism was evaluated by the OGTT ( G ) and ITT ( H ) in four groups of mice ( n = 5). ( I ) HE histopathological staining of the pancreas, spleen, liver, kidney and heart of the four groups of mice ( n = 3). ( J-N ) Concentration monitoring of multiple organ function impairment markers in the serum of the four groups of mice ( n = 6). * P < 0.05 ; ** P < 0.01; *** P < 0.001; ns ( P > 0.05) . Scale bars: Pancreas, 400 μm; other tissues, 200 μm
    Figure Legend Snippet: S961 and ATN-224 partially reversed the therapeutic effect of hucMSC-EXOs on T1DM mice. ( A ) Schematic diagram shows the treatment plan for T1DM mice with S961, ATN-224 and hucMSC-EXOs. ( B ) Images of T1DM, EXO, EXO + S961, EXO + ATN-224 mice. ( C-F ) Physiological and metabolic indices, including food intake ( C ), water intake ( D ), body weight ( E ), and blood glucose levels ( F ), of the mice in the four groups. ( n = 6). ( G-H ) Glucose metabolism was evaluated by the OGTT ( G ) and ITT ( H ) in four groups of mice ( n = 5). ( I ) HE histopathological staining of the pancreas, spleen, liver, kidney and heart of the four groups of mice ( n = 3). ( J-N ) Concentration monitoring of multiple organ function impairment markers in the serum of the four groups of mice ( n = 6). * P < 0.05 ; ** P < 0.01; *** P < 0.001; ns ( P > 0.05) . Scale bars: Pancreas, 400 μm; other tissues, 200 μm

    Techniques Used: Staining, Concentration Assay

    S961 and ATN-224 reversed the hucMSC-EXOs-mediated anti-inflammatory in multiple organs. ( A-D ) IHC staining of F4/80 in the pancreas ( A ), spleen ( B ), liver ( C ), and heart ( D ) of CON, T1DM, EXO, EXO + S961, EXO + ATN-224 group mice ( n = 3). ( E-G ) Flow cytometry detects the F4/80-positive macrophages in the pancreas ( E ), spleen ( F ), and liver ( G ) via flow cytometry ( n = 4). ( H-P ) Flow cytometry analysis the protein levels of IL-6, CCL-2, and TNF-α in infiltrating macrophages from the pancreas ( H-J ), spleen ( K-M ), and liver ( N-P ), ( n = 4) . * P < 0.05 ; ** P < 0.01 ; *** P < 0.001 . Scale bars: Pancreas, 400 μm; other tissues, 200 μm
    Figure Legend Snippet: S961 and ATN-224 reversed the hucMSC-EXOs-mediated anti-inflammatory in multiple organs. ( A-D ) IHC staining of F4/80 in the pancreas ( A ), spleen ( B ), liver ( C ), and heart ( D ) of CON, T1DM, EXO, EXO + S961, EXO + ATN-224 group mice ( n = 3). ( E-G ) Flow cytometry detects the F4/80-positive macrophages in the pancreas ( E ), spleen ( F ), and liver ( G ) via flow cytometry ( n = 4). ( H-P ) Flow cytometry analysis the protein levels of IL-6, CCL-2, and TNF-α in infiltrating macrophages from the pancreas ( H-J ), spleen ( K-M ), and liver ( N-P ), ( n = 4) . * P < 0.05 ; ** P < 0.01 ; *** P < 0.001 . Scale bars: Pancreas, 400 μm; other tissues, 200 μm

    Techniques Used: Immunohistochemistry, Flow Cytometry



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    ins receptor antagonist s961  (MedChemExpress)
    93
    MedChemExpress ins receptor antagonist s961
    Anti-inflammatory protein components in hucMSC-EXOs. ( A-F ) qPCR was performed to compare the effects of heat-inactivated hucMSC-EXOs and untreated hucMSC-EXOs on the expression levels of inflammatory cytokines in macrophages. ( G ) Topological analysis of hucMSC-EXOs proteins (top 200 by IBAQ value) via the STRING database, identifying the top 40 hub proteins ranked by interaction degree. Their degrees of interaction are visualized as a concentric circle plot. ( H-K ) ELISA was used to detect the <t>INS</t> ( H-I ) content and SOD1 ( J-K ) content of the hucMSCs culture supernatant and hucMSC-EXOs. (L‒O) qPCR analysis the effects of EXO alone, EXO combined with <t>S961,</t> and EXO combined with ATN-224 on the expression of inflammatory factors in macrophages. ( P ) WB experiment analysis the influence of EXO alone, EXO combined with S961, and EXO combined with ATN-224 treatment on PI3K/AKT and P65 phosphorylation in macrophages. * P < 0.05; ** P < 0.01 ; *** P < 0.001
    Ins Receptor Antagonist S961, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ins receptor antagonist s961/product/MedChemExpress
    Average 93 stars, based on 1 article reviews
    ins receptor antagonist s961 - by Bioz Stars, 2026-02
    93/100 stars
    		  Buy from Supplier

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    Anti-inflammatory protein components in hucMSC-EXOs. ( A-F ) qPCR was performed to compare the effects of heat-inactivated hucMSC-EXOs and untreated hucMSC-EXOs on the expression levels of inflammatory cytokines in macrophages. ( G ) Topological analysis of hucMSC-EXOs proteins (top 200 by IBAQ value) via the STRING database, identifying the top 40 hub proteins ranked by interaction degree. Their degrees of interaction are visualized as a concentric circle plot. ( H-K ) ELISA was used to detect the INS ( H-I ) content and SOD1 ( J-K ) content of the hucMSCs culture supernatant and hucMSC-EXOs. (L‒O) qPCR analysis the effects of EXO alone, EXO combined with S961, and EXO combined with ATN-224 on the expression of inflammatory factors in macrophages. ( P ) WB experiment analysis the influence of EXO alone, EXO combined with S961, and EXO combined with ATN-224 treatment on PI3K/AKT and P65 phosphorylation in macrophages. * P < 0.05; ** P < 0.01 ; *** P < 0.001

    Journal: Stem Cell Research & Therapy

    Article Title: hucMSC-derived exosomes targeting macrophage polarization attenuate systemic inflammation in T1DM via INS/SOD1 delivery

    doi: 10.1186/s13287-025-04521-0

    Figure Lengend Snippet: Anti-inflammatory protein components in hucMSC-EXOs. ( A-F ) qPCR was performed to compare the effects of heat-inactivated hucMSC-EXOs and untreated hucMSC-EXOs on the expression levels of inflammatory cytokines in macrophages. ( G ) Topological analysis of hucMSC-EXOs proteins (top 200 by IBAQ value) via the STRING database, identifying the top 40 hub proteins ranked by interaction degree. Their degrees of interaction are visualized as a concentric circle plot. ( H-K ) ELISA was used to detect the INS ( H-I ) content and SOD1 ( J-K ) content of the hucMSCs culture supernatant and hucMSC-EXOs. (L‒O) qPCR analysis the effects of EXO alone, EXO combined with S961, and EXO combined with ATN-224 on the expression of inflammatory factors in macrophages. ( P ) WB experiment analysis the influence of EXO alone, EXO combined with S961, and EXO combined with ATN-224 treatment on PI3K/AKT and P65 phosphorylation in macrophages. * P < 0.05; ** P < 0.01 ; *** P < 0.001

    Article Snippet: THP-1 cells were differentiated into M0 macrophages with 100 nM phorbol myristate acetate (PMA; HY-18739, MCE, US) for 24 h, and then divided into six experimental groups: PMA control, lipopolysaccharide (LPS; 50 ng/mL; L2880, Sigma, US), LPS + 5 nM INS (GC2646, Genxion, China), LPS + 1 μg SOD1 (HY-P71048A, MCE, US), LPS + hucMSC-EXOs (8.5 × 10^5 particles), LPS + heat-inactivated hucMSC-EXOs (8.5 × 10^5 particles), LPS + hucMSC-EXOs + 5 nM INS receptor antagonist S961 (HY-P2093B, MCE, US), and LPS + hucMSC-EXOs + 20 nM SOD1 inhibitor ATN-224 (HY-16074, MCE, US).

    Techniques: Expressing, Enzyme-linked Immunosorbent Assay, Phospho-proteomics

    S961 and ATN-224 partially reversed the therapeutic effect of hucMSC-EXOs on T1DM mice. ( A ) Schematic diagram shows the treatment plan for T1DM mice with S961, ATN-224 and hucMSC-EXOs. ( B ) Images of T1DM, EXO, EXO + S961, EXO + ATN-224 mice. ( C-F ) Physiological and metabolic indices, including food intake ( C ), water intake ( D ), body weight ( E ), and blood glucose levels ( F ), of the mice in the four groups. ( n = 6). ( G-H ) Glucose metabolism was evaluated by the OGTT ( G ) and ITT ( H ) in four groups of mice ( n = 5). ( I ) HE histopathological staining of the pancreas, spleen, liver, kidney and heart of the four groups of mice ( n = 3). ( J-N ) Concentration monitoring of multiple organ function impairment markers in the serum of the four groups of mice ( n = 6). * P < 0.05 ; ** P < 0.01; *** P < 0.001; ns ( P > 0.05) . Scale bars: Pancreas, 400 μm; other tissues, 200 μm

    Journal: Stem Cell Research & Therapy

    Article Title: hucMSC-derived exosomes targeting macrophage polarization attenuate systemic inflammation in T1DM via INS/SOD1 delivery

    doi: 10.1186/s13287-025-04521-0

    Figure Lengend Snippet: S961 and ATN-224 partially reversed the therapeutic effect of hucMSC-EXOs on T1DM mice. ( A ) Schematic diagram shows the treatment plan for T1DM mice with S961, ATN-224 and hucMSC-EXOs. ( B ) Images of T1DM, EXO, EXO + S961, EXO + ATN-224 mice. ( C-F ) Physiological and metabolic indices, including food intake ( C ), water intake ( D ), body weight ( E ), and blood glucose levels ( F ), of the mice in the four groups. ( n = 6). ( G-H ) Glucose metabolism was evaluated by the OGTT ( G ) and ITT ( H ) in four groups of mice ( n = 5). ( I ) HE histopathological staining of the pancreas, spleen, liver, kidney and heart of the four groups of mice ( n = 3). ( J-N ) Concentration monitoring of multiple organ function impairment markers in the serum of the four groups of mice ( n = 6). * P < 0.05 ; ** P < 0.01; *** P < 0.001; ns ( P > 0.05) . Scale bars: Pancreas, 400 μm; other tissues, 200 μm

    Article Snippet: THP-1 cells were differentiated into M0 macrophages with 100 nM phorbol myristate acetate (PMA; HY-18739, MCE, US) for 24 h, and then divided into six experimental groups: PMA control, lipopolysaccharide (LPS; 50 ng/mL; L2880, Sigma, US), LPS + 5 nM INS (GC2646, Genxion, China), LPS + 1 μg SOD1 (HY-P71048A, MCE, US), LPS + hucMSC-EXOs (8.5 × 10^5 particles), LPS + heat-inactivated hucMSC-EXOs (8.5 × 10^5 particles), LPS + hucMSC-EXOs + 5 nM INS receptor antagonist S961 (HY-P2093B, MCE, US), and LPS + hucMSC-EXOs + 20 nM SOD1 inhibitor ATN-224 (HY-16074, MCE, US).

    Techniques: Staining, Concentration Assay

    S961 and ATN-224 reversed the hucMSC-EXOs-mediated anti-inflammatory in multiple organs. ( A-D ) IHC staining of F4/80 in the pancreas ( A ), spleen ( B ), liver ( C ), and heart ( D ) of CON, T1DM, EXO, EXO + S961, EXO + ATN-224 group mice ( n = 3). ( E-G ) Flow cytometry detects the F4/80-positive macrophages in the pancreas ( E ), spleen ( F ), and liver ( G ) via flow cytometry ( n = 4). ( H-P ) Flow cytometry analysis the protein levels of IL-6, CCL-2, and TNF-α in infiltrating macrophages from the pancreas ( H-J ), spleen ( K-M ), and liver ( N-P ), ( n = 4) . * P < 0.05 ; ** P < 0.01 ; *** P < 0.001 . Scale bars: Pancreas, 400 μm; other tissues, 200 μm

    Journal: Stem Cell Research & Therapy

    Article Title: hucMSC-derived exosomes targeting macrophage polarization attenuate systemic inflammation in T1DM via INS/SOD1 delivery

    doi: 10.1186/s13287-025-04521-0

    Figure Lengend Snippet: S961 and ATN-224 reversed the hucMSC-EXOs-mediated anti-inflammatory in multiple organs. ( A-D ) IHC staining of F4/80 in the pancreas ( A ), spleen ( B ), liver ( C ), and heart ( D ) of CON, T1DM, EXO, EXO + S961, EXO + ATN-224 group mice ( n = 3). ( E-G ) Flow cytometry detects the F4/80-positive macrophages in the pancreas ( E ), spleen ( F ), and liver ( G ) via flow cytometry ( n = 4). ( H-P ) Flow cytometry analysis the protein levels of IL-6, CCL-2, and TNF-α in infiltrating macrophages from the pancreas ( H-J ), spleen ( K-M ), and liver ( N-P ), ( n = 4) . * P < 0.05 ; ** P < 0.01 ; *** P < 0.001 . Scale bars: Pancreas, 400 μm; other tissues, 200 μm

    Article Snippet: THP-1 cells were differentiated into M0 macrophages with 100 nM phorbol myristate acetate (PMA; HY-18739, MCE, US) for 24 h, and then divided into six experimental groups: PMA control, lipopolysaccharide (LPS; 50 ng/mL; L2880, Sigma, US), LPS + 5 nM INS (GC2646, Genxion, China), LPS + 1 μg SOD1 (HY-P71048A, MCE, US), LPS + hucMSC-EXOs (8.5 × 10^5 particles), LPS + heat-inactivated hucMSC-EXOs (8.5 × 10^5 particles), LPS + hucMSC-EXOs + 5 nM INS receptor antagonist S961 (HY-P2093B, MCE, US), and LPS + hucMSC-EXOs + 20 nM SOD1 inhibitor ATN-224 (HY-16074, MCE, US).

    Techniques: Immunohistochemistry, Flow Cytometry